John Guy Selected Research

NADH dehydrogenase subunit 4

1/2013	Next-generation sequencing of mitochondrial targeted AAV transfer of human ND4 in mice.
1/2012	Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice.

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John Guy Research Topics

Disease

15	Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) 01/2022 - 02/2003
7	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/2020 - 10/2006
6	Mitochondrial Diseases (Mitochondrial Disease) 04/2020 - 04/2002
4	Multiple Sclerosis 04/2020 - 01/2007
4	Ganglion Cysts (Ganglion) 01/2016 - 03/2003
4	Optic Nerve Diseases (Optic Neuropathy) 10/2014 - 02/2003
4	Optic Neuritis (Retrobulbar Neuritis) 07/2013 - 01/2007
4	Demyelinating Diseases (Demyelinating Disease) 07/2013 - 02/2003
2	Blindness (Hysterical Blindness) 10/2015 - 01/2012
2	Optic Atrophy 07/2014 - 01/2012
1	Uveitis 01/2022
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2022
1	Atrophy 10/2020
1	Cholesteatoma 06/2020
1	Disease Progression 01/2020
1	Hemorrhage 03/2016
1	Pharyngitis (Sore Throat) 03/2016
1	Keratitis 03/2016
1	Encephalomyelitis (Myeloencephalitis) 07/2014
1	Inflammation (Inflammations) 07/2013
1	Retinal Degeneration 07/2010
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 03/2009
1	Retinal Dystrophies 02/2008
1	Abducens Nerve Diseases (Sixth Nerve Palsy) 01/2007
1	Maternally Inherited Leigh Syndrome 04/2002
1	Neuropathy ataxia and retinitis pigmentosa 04/2002

Drug/Important Bio-Agent (IBA)

8	Mitochondrial DNA (mtDNA)IBA 01/2022 - 04/2002
5	AntioxidantsIBA 01/2008 - 01/2007
4	Electron Transport Complex I (NADH-CoQ Reductase)IBA 01/2022 - 01/2012
3	Adenosine Triphosphate (ATP)IBA 09/2009 - 04/2002
3	Catalytic RNA (Ribozymes)IBA 08/2004 - 02/2003
2	Neutralizing AntibodiesIBA 01/2022 - 03/2016
2	Retinaldehyde (Retinal)IBA 10/2020 - 01/2016
2	NADH DehydrogenaseIBA 04/2020 - 10/2013
2	NAD (NADH)IBA 01/2020 - 04/2014
2	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 04/2014
2	Proteins (Proteins, Gene)FDA Link 07/2013 - 10/2006
2	NADH dehydrogenase subunit 4IBA 01/2013 - 01/2012
2	EnzymesIBA 11/2008 - 01/2007
2	CatalaseIBA 12/2007 - 01/2007
2	Superoxide DismutaseIBA 01/2007 - 03/2003
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2007 - 03/2003
1	DNA (Deoxyribonucleic Acid)IBA 01/2022
1	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 07/2014
1	Myelin-Oligodendrocyte GlycoproteinIBA 07/2013
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 07/2013
1	Methylprednisolone FDA LinkGeneric 01/2010
1	Prednisone (Sone)FDA LinkGeneric 01/2010
1	Green Fluorescent ProteinsIBA 12/2009
1	LipidsIBA 03/2009
1	CholesterolIBA 03/2009
1	Triglycerides (Triacylglycerol)IBA 03/2009
1	ApolipoproteinsIBA 03/2009
1	LDL CholesterolIBA 03/2009
1	oxidized low density lipoproteinIBA 03/2009
1	Lipoproteins (Lipoprotein)IBA 03/2009
1	HDL CholesterolIBA 03/2009
1	Cone OpsinsIBA 02/2008
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2007
1	Superoxides (Superoxide)IBA 01/2007
1	Bevacizumab (Avastin)FDA Link 01/2007
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 10/2006
1	Messenger RNA (mRNA)IBA 02/2003
1	Peptides (Polypeptides)IBA 04/2002
1	oligomycin sensitivity-conferring protein (complex V)IBA 04/2002
1	Adenosine Triphosphatases (ATPase)IBA 04/2002

Therapy/Procedure

4	Therapeutics 01/2022 - 12/2007
2	Intraocular Injections 10/2015 - 12/2007
1	Endoscopes 06/2020
1	Intravitreal Injections 07/2014
1	Injections 04/2012
1	Glycemic Control 03/2009